#Panyawan/Makabuhay/Tinospora Cordifolia – accdg. to the research panyawan can modulate Glut-4 and the predominant protein that influences glucose metabolism. Thus, it is good for people who have diabetes.

Panyawan, as we call it in Mindanao, is an herbaceous vine that is found throughout the Philippines. In Tagalog, it is called Makabuhay which literally means “to give life” in English.

Panyawan is a native plant from tropical and subtropical rain forest in India, Myanmar, Sri Lanka, and Philippines. It belongs to the family of Menispermaceae. It has long history of medicinal use in India. In Ayurveda (Hindu traditional), panyawan is considered one of the most divine herbs. It is use to promote longevity, prevent deseases and to treat various illness from arthritis to cancer. In the Philippines, panyawan extract combined with oil is used to treat rheumatism and arthritis, abdominal pains, scabies, and skin ulcers.

According to the research conducted in the Indian Medicine Research Laboratory, panyawan can modulate Glut-4 and the predominant protein that influences glucose metabolism. Thus, it is good for people who have diabetes. However, this medicinal plant is generally for tropical application and moderate intake only. Pregnant and lactating women should avoid taking this.

Other names of Tinospora Cordifolia known by – Ambervel, Amrita, Gilo, Giloe, Giloya, Glunchanb, Guduchi, Gulancha, Tinospora, Gulvel, Gurcha, Heart-Leaved Moonseed, Heavenly Elixir, Indian Tinospora, Jetwatika, Moonseed, T. Cordifolia, TC, TCRE, TCRET, Tinospora, Tinospora Indien, Tinosporia Cordifolus.

What is Tinospora Cordifolia?

Tinospora cordifolia is used for diabetes, high cholesterol, allergic rhinitis (hay fever), upset stomach, gout, lymphoma and other cancers, rheumatoid arthritis (RA), hepatitis, peptic ulcer disease (PUD), fever, gonorrhea, syphilis, and to boost the immune system.

● Allergies (HayFever). A particular extract of Tinospora Cordifolia (Tinofend, Verdure Sciences) seems to significantly decrease sneezing and nasal itching, discharge, and stuffy nose after about 2 months of treatment.


Tinospora cordifolia contains many different chemicals that might affect the body. Some of these chemicals have antioxidant effects. Others might increase the activity of the body’s immune system. Some chemicals might have activity against cancer cells in test animals. Most research has been done in test tubes or in animals. There isn’t enough information to know the effects of Tinospora cordifolia in the human body.


Tinospora cordifolia seems to be safe when used short-term. The safety of long-term use, more than 8 weeks, is not known.


Pregnancy and Breast -feeding – not enough is known about the use of Tinospora cordifolia during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Diabetes – Tinospora cordifolia might lower blood sugar levels. Use it cautiously if you have diabetes, and monitor your blood sugar levels. The doses of your diabetes medications might need to be adjusted.

“Autoimmune diseases” such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions:

¤ Tinospora cordifolia might cause the immune system to become more active, and this could increase the symptoms of autoimmune disease. If you have one of these conditions, it’s best to avoid Tinospora cordifolia.

● Surgery – Tinospora cordifolia might affect blood sugar levels, so there is a concern that it might interfere with blood sugar control during and after surgery. Stop taking Tinospora cordifolia at least 2 weeks before a scheduled surgery.

Are there any interactions with medications?

Medications for diabetes (Antidiabetes drugs) Interaction Rating: Moderate be cautious with this combination. Talk with your health procider.

¤ Tinospora cordifolia might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Diabetes medications are also used to lower blood sugar. Taking Tinospora cordifolia along with diabetes medications might cause your blood sugar to go to low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

¤ Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Medications that decrease the immune system (Immunosuppressants) Interaction Rating: Moderate Be cautious with this combination. Talk with your health provider.

¤ Tinospora cordifolia might increase the immune system. Taking it along with some medications that decrease the immune system might decrease the effectiveness of these medications.

¤ Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Dosing considerations for Tinospora Cordifolia.

The following doses have been studied in scientific research:


● For allergic rhinitis (hay fever): 300mg of a specific Tinospora cordifolia aqueous stem extract (Tinofend, Verdure Sciences) three times daily for 8 weeks.

References: rxlist.com / innerwellness.weebly.com

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